Nea Anchialos National Airport
This airport has international and domestic flights from Volos, Greece and is 129 km from the center of Trikala, Greece.
Trains OSE connect Trikala to other cities in Greece. Travelling with ordinary trains can be cheaper, although a little bit slower, whereas choosing a fancy faster Intercity train will cost the same amount of money, or even more than a KTEL bus.
There is a highway from Athens to Lamia and from there a national road links Lamia to Trikala (331 km) and then to Kalambaka.